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In-depth understanding of the working principle and technical characteristics of R&D Automatic Peptide Synthesizer

Release Time:2024-04-15

Number of views:160

  R&D Automatic Peptide Synthesizer is an automated instrument for synthesizing peptides, which is widely used in biotechnology, drug development and other fields.


  I. Working Principle

  The basic working principle of R&D Automatic Peptide Synthesizer is based on solid phase peptide synthesis technology. This technology adopts a step-by-step addition of amino acids to synthesize peptides on a solid-phase carrier. The main steps are as follows:

  1. Activation: Mix the solid-phase carrier with amino acid activator, so that the amino acid combines with the solid-phase carrier to form an active ester.


  2. Linkage: The next amino acid is linked to the formed active ester to form a peptide bond. This step is repeated until the desired peptide is synthesized.


  3. Deprotection: Removal of protective groups from amino acid residues on the peptide chain, exposing them to the surface of the molecule.


  4. Purification: purify the synthesized peptide by chromatography and crystallization to remove unreacted raw materials and by-products.


  5. Sequencing: Determine the sequence of the synthesized peptide by mass spectrometry, nuclear magnetic resonance and other methods.

R&D Automatic Peptide Synthesizer

  Technical features

  1. High degree of automation: It integrates all steps of peptide synthesis, from amino acid activation, peptide bond formation to deprotection and purification, all of which can be automated. Users only need to set the synthesis parameters to obtain the required peptide products.


  2. Fast synthesis speed: the advanced reactor design improves the reaction rate and mass transfer effect, and shortens the time of peptide synthesis.


  3. Flexible scale of synthesis: the scale of synthesis can be adjusted according to the demand, from small-scale laboratory research to large-scale industrialized production are applicable.


  4. Controllable reaction conditions: the reaction temperature, pressure, time and other parameters can be precisely controlled to ensure the stability and reproducibility of peptide synthesis.


  5. High degree of system integration: integrating a variety of functional modules, such as amino acid storage tanks, reactors, purification systems, etc., occupying a small space, easy to operate.


  6. Good environmental performance: adopting environmentally friendly solvents and catalysts to reduce pollution to the environment. Meanwhile, the design of the instrument meets the safety standards to ensure the personal safety of the operators.


  R&D Automatic Peptide Synthesizer plays an important role in biotechnology, drug development and other fields with its high efficiency, rapidity and flexibility. In practical application, a suitable peptide synthesizer should be selected according to specific needs to improve the efficiency and quality of peptide synthesis.

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