Single-channel peptide synthesizers are key technologies for automated peptide chain synthesis

　　In order to meet the growing applications of peptides in medicine, agriculture, food and other fields, automated peptide chain synthesis technology has emerged. Among them, single-channel peptide synthesizer, as a key technology, provides strong support for the realization of automated peptide chain synthesis.

　　I. Working Principle

　　The single-channel peptide synthesizer adopts the solid-phase synthesis method, which realizes the automated peptide chain synthesis by adding amino acids one by one to the peptide chain immobilized on the carrier. During the synthesis process, the reaction conditions, such as temperature, pH, reaction time, etc., can be automatically adjusted according to the preset program to ensure the smooth progress of peptide chain synthesis.

　　II. Advantages

　　1、Efficiency: compared with the traditional liquid phase synthesis method, the peptide chain synthesis can be completed in a shorter time, which greatly improves the synthesis efficiency.

　　2、Precision: the addition amount of each amino acid and the reaction conditions can be precisely controlled, so as to ensure that the sequence and structure of the peptide chain are in accordance with the expectations.

　　3、High degree of automation: It can realize the automation of the whole process from the addition of amino acids to the separation of peptide chain, which reduces the human error and improves the repeatability and reliability of the experiment.

　　4、Flexibility: the synthesis strategy can be flexibly adjusted according to the experimental needs, such as changing the amino acid sequence, adding protective groups and so on.

　　III.Application in automated peptide chain synthesis

　　It has wide application prospects in automated peptide chain synthesis. It can be used to synthesize peptide compounds with specific functions, such as antibodies, enzyme inhibitors, hormones and so on. In addition, the single-channel peptide synthesizer can also be used to study the relationship between peptide chain structure and function, providing an important basis for drug design.